T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes.

The T3 complex on human T lymphocytes involves four structurally distinct glycoproteins.

Monoclonal antibodies allow for the detection of antigens which are specific for human thymus-derived lymphocytes. Among these antigens, the T3 complex is of particular interest since it is involved in several T cell functions. The main target antigen of the anti-T3 reagents is borne by a 20-kDa glycoprotein. In addition, glycoproteins of 25-28, 37, and 44 kDa are found in anti-T3 immunoprecipi...

Surface expression of functional T cell receptor chains formed by interlocus recombination on human T lymphocytes

Structural diversity of lymphocyte antigen receptors (the immunoglobulin [Ig] of B cells and the alpha/beta or gamma/delta T cell receptor [TCR] of T cells) is generated through somatic rearrangements of V, D, and J gene segments. Classically, these recombination events involve gene segments from the same Ig or TCR locus. However, occurrence of "trans" rearrangements between distinct loci has a...

T cell gamma receptor.

T-Cell Receptor/CD28-Mediated Activation of Human T Lymphocytes Induces Expression of Functional -Opioid Receptors

Opiates function as immunomodulators, partly by their effects on T cells. Opioids act via -, -, and -opioid receptors, among which the -type is of particular interest, because morphine-like opioids preferentially bind to it. Here we report that -opioid receptor mRNA was induced after CD3/28-mediated activation of primary human T lymphocytes and Jurkat T cells, neither of which expresses the gen...

Distinct molecular forms of human T cell receptor gamma/delta detected on viable T cells by a monoclonal antibody

A second type of TCR molecule has been identified on human and murine T lymphocytes, which involves the protein products of the gamma and delta genes. T lymphocytes bearing this receptor may constitute a separate cell lineage with a distinct immune function. We have produced an mAb, which specifically detects human TCR-gamma/delta in native as well as denatured states, this in contrast to previ...